Lower Alexandria is south of the Duke Street corridor. There are communities of small homes, rowhouses, and townhomes. Commercial and retail real estate includes the Foxchase Shopping Center.

The section between Wheeler Ave. and Jordan St. is also known as the "Block." In the 1960s and 1970s, this section of Alexandria was also known because of Shirley Duke, a complex of 2,214 low-priced rental apartments, which became the Foxchase development in the early 1980s after five years of stagnancy.

There are also areas of industrial businesses south of Duke Street, primarily off Wheeler Ave., South Pickett Street, and South Van Dorn Street.

In the very southern part of this area is the Eisenhower Avenue corridor running parallel to the Capital Beltway (I-95/I-495) and west of Telegraph Rd, which is primarily industrial and commercial in nature. There has been some development in apartments and townhomes in the area west of Telegraph Road and east of Clermont Avenue along with Class 1 Offices and national brand hotels. The Van Dorn Metro Station here provides access to Washington, D.C.